元学习是机器学习的一个分支，它训练神经网络模型以合成各种数据，以快速解决新问题。在过程控制中，许多系统具有相似且充分理解的动力学，这表明可以通过元学习创建可推广的控制器是可行的。在这项工作中，我们制定了一种元加强学习（META-RL）控制策略，该策略可用于调整比例的整体控制器。我们的Meta-RL代理具有复发结构，该结构累积了“上下文”，以通过闭环中的隐藏状态变量学习系统的动力学。该体系结构使代理能够自动适应过程动力学的变化。在此处报告的测试中，对元RL代理完全离线训练了一阶和时间延迟系统，并从相同的训练过程动力学分布中得出的新型系统产生了出色的效果。一个关键的设计元素是能够在模拟环境中训练期间离线利用基于模型的信息，同时保持无模型的策略结构，以与真实过程动态不确定性的新过程进行交互。元学习是一种构建样品有效智能控制器的有前途的方法。

深度加强学习（RL）是一种优化驱动的框架，用于生产一般动力系统的控制策略，而无明确依赖过程模型。仿真报告了良好的结果。在这里，我们展示了在真实物理系统上实现了艺术深度RL算法状态的挑战。方面包括软件与现有硬件之间的相互作用;实验设计和样品效率;培训受输入限制;和算法和控制法的解释性。在我们的方法中，我们的方法是使用PID控制器作为培训RL策略。除了简单性之外，这种方法还具有多种吸引力功能：无需将额外的硬件添加到控制系统中，因为PID控制器可以通过标准可编程逻辑控制器轻松实现;控制法可以在参数空间的“安全”区域中很容易初始化;最终产品 - 一个调整良好的PID控制器 - 有一种形式，从业者可以充分推理和部署。

元学习是机器学习的一个分支，旨在将相关任务分布的数据合成以有效地解决新的数据。在过程控制中，许多系统具有相似且充分理解的动力学，这表明可以通过元学习创建可推广的控制器是可行的。在这项工作中，我们制定了一种元加强学习（META-RL）控制策略，该策略利用已知的离线信息进行培训，例如模型结构。对模型参数的分布而不是单个模型，对元RL代理进行了训练，从而使代理能够自动适应过程动力学的变化，同时保持性能。一个关键的设计元素是能够在培训期间离线利用基于模型的信息，同时保持与新环境交互的无模型策略结构。我们以前的工作已经证明了如何将这种方法应用于调整比例综合控制器以控制一阶过程的与工业相关的问题。在这项工作中，我们简要地重新引入了我们的方法，并证明了如何将其扩展到比例综合衍生的控制器和二阶系统。

Data-driven models such as neural networks are being applied more and more to safety-critical applications, such as the modeling and control of cyber-physical systems. Despite the flexibility of the approach, there are still concerns about the safety of these models in this context, as well as the need for large amounts of potentially expensive data. In particular, when long-term predictions are needed or frequent measurements are not available, the open-loop stability of the model becomes important. However, it is difficult to make such guarantees for complex black-box models such as neural networks, and prior work has shown that model stability is indeed an issue. In this work, we consider an aluminum extraction process where measurements of the internal state of the reactor are time-consuming and expensive. We model the process using neural networks and investigate the role of including skip connections in the network architecture as well as using l1 regularization to induce sparse connection weights. We demonstrate that these measures can greatly improve both the accuracy and the stability of the models for datasets of varying sizes.

A comprehensive pharmaceutical recommendation system was designed based on the patients and drugs features extracted from Drugs.com and Druglib.com. First, data from these databases were combined, and a dataset of patients and drug information was built. Secondly, the patients and drugs were clustered, and then the recommendation was performed using different ratings provided by patients, and importantly by the knowledge obtained from patients and drug specifications, and considering drug interactions. To the best of our knowledge, we are the first group to consider patients conditions and history in the proposed approach for selecting a specific medicine appropriate for that particular user. Our approach applies artificial intelligence (AI) models for the implementation. Sentiment analysis using natural language processing approaches is employed in pre-processing along with neural network-based methods and recommender system algorithms for modeling the system. In our work, patients conditions and drugs features are used for making two models based on matrix factorization. Then we used drug interaction to filter drugs with severe or mild interactions with other drugs. We developed a deep learning model for recommending drugs by using data from 2304 patients as a training set, and then we used data from 660 patients as our validation set. After that, we used knowledge from critical information about drugs and combined the outcome of the model into a knowledge-based system with the rules obtained from constraints on taking medicine.

We test the performance of GAN models for lip-synchronization. For this, we reimplement LipGAN in Pytorch, train it on the dataset GRID and compare it to our own variation, L1WGAN-GP, adapted to the LipGAN architecture and also trained on GRID.

High content imaging assays can capture rich phenotypic response data for large sets of compound treatments, aiding in the characterization and discovery of novel drugs. However, extracting representative features from high content images that can capture subtle nuances in phenotypes remains challenging. The lack of high-quality labels makes it difficult to achieve satisfactory results with supervised deep learning. Self-Supervised learning methods, which learn from automatically generated labels has shown great success on natural images, offer an attractive alternative also to microscopy images. However, we find that self-supervised learning techniques underperform on high content imaging assays. One challenge is the undesirable domain shifts present in the data known as batch effects, which may be caused by biological noise or uncontrolled experimental conditions. To this end, we introduce Cross-Domain Consistency Learning (CDCL), a novel approach that is able to learn in the presence of batch effects. CDCL enforces the learning of biological similarities while disregarding undesirable batch-specific signals, which leads to more useful and versatile representations. These features are organised according to their morphological changes and are more useful for downstream tasks - such as distinguishing treatments and mode of action.

Objective: Imbalances of the electrolyte concentration levels in the body can lead to catastrophic consequences, but accurate and accessible measurements could improve patient outcomes. While blood tests provide accurate measurements, they are invasive and the laboratory analysis can be slow or inaccessible. In contrast, an electrocardiogram (ECG) is a widely adopted tool which is quick and simple to acquire. However, the problem of estimating continuous electrolyte concentrations directly from ECGs is not well-studied. We therefore investigate if regression methods can be used for accurate ECG-based prediction of electrolyte concentrations. Methods: We explore the use of deep neural networks (DNNs) for this task. We analyze the regression performance across four electrolytes, utilizing a novel dataset containing over 290000 ECGs. For improved understanding, we also study the full spectrum from continuous predictions to binary classification of extreme concentration levels. To enhance clinical usefulness, we finally extend to a probabilistic regression approach and evaluate different uncertainty estimates. Results: We find that the performance varies significantly between different electrolytes, which is clinically justified in the interplay of electrolytes and their manifestation in the ECG. We also compare the regression accuracy with that of traditional machine learning models, demonstrating superior performance of DNNs. Conclusion: Discretization can lead to good classification performance, but does not help solve the original problem of predicting continuous concentration levels. While probabilistic regression demonstrates potential practical usefulness, the uncertainty estimates are not particularly well-calibrated. Significance: Our study is a first step towards accurate and reliable ECG-based prediction of electrolyte concentration levels.

How can we accurately identify new memory workloads while classifying known memory workloads? Verifying DRAM (Dynamic Random Access Memory) using various workloads is an important task to guarantee the quality of DRAM. A crucial component in the process is open-set recognition which aims to detect new workloads not seen in the training phase. Despite its importance, however, existing open-set recognition methods are unsatisfactory in terms of accuracy since they fail to exploit the characteristics of workload sequences. In this paper, we propose Acorn, an accurate open-set recognition method capturing the characteristics of workload sequences. Acorn extracts two types of feature vectors to capture sequential patterns and spatial locality patterns in memory access. Acorn then uses the feature vectors to accurately classify a subsequence into one of the known classes or identify it as the unknown class. Experiments show that Acorn achieves state-of-the-art accuracy, giving up to 37% points higher unknown class detection accuracy while achieving comparable known class classification accuracy than existing methods.

As spatial audio is enjoying a surge in popularity, data-driven machine learning techniques that have been proven successful in other domains are increasingly used to process head-related transfer function measurements. However, these techniques require much data, whereas the existing datasets are ranging from tens to the low hundreds of datapoints. It therefore becomes attractive to combine multiple of these datasets, although they are measured under different conditions. In this paper, we first establish the common ground between a number of datasets, then we investigate potential pitfalls of mixing datasets. We perform a simple experiment to test the relevance of the remaining differences between datasets when applying machine learning techniques. Finally, we pinpoint the most relevant differences.